WhoWe Are
Centre for Clinical Outcome Research (CCORe), formerly known as Healthcare Statistic Unit, aims to become a leading centre in evaluating and improving clinical and health outcomes through impactful research.
Vision:
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To produce useful research evidence using robust and transparent methodology to inform policy and practice
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To nurture and to cultivate an outstanding and a high performing team to drive excellence in research
Mission:
To provide services & management of healthcare research effectively through a well-organized system in line with Institutional Objectives
OrganizationChart
InvestigatorsHighlight
Head, Centre for Clinical Outcomes Research (CCORe)
Email: petertok@moh.gov.my
BMedSc (Melb), MD (UI), MPH (UM), DrPH (UM)
Areas of interest: Public health, Epidemiology, Infectious diseases
Awards and achievements:
- Gazetted as Public Health Medicine Specialist – 2022
- Excellent Service Award (APC) – 2016
- Good Clinical Practice (GCP) certified – 2015
Dr. Peter Tok is a public health medicine specialist and the current head of CCORe, ICR. He graduated from the University of Indonesia in 2012 before completing his MPH (2018) and DrPH (2022) at the University of Malaya. Dr. Tok’s area of interest is in the epidemiology of infectious diseases; his DrPH thesis explored on the determinants of tuberculosis treatment outcomes in Malaysia. During the recent COVID-19 pandemic, he has embarked on projects involving COVID-19 vaccine surveillance, in particular, the Real-World Evaluation of COVID-19 Vaccines under the Malaysia National COVID-19 Immunisation Program (RECoVaM)
Research Highlights
RECoVaM project looked into the real-world evaluation of COVID-19 vaccines under the national COVID-19 immunisation program in Malaysia. Study findings benefitted policymakers and peer-reviewed publications from this project were widely cited. Refer link for more details: https://linktr.ee/recovamys
Recent Publications
Pharmacist
Email: norazida.ar@moh.gov.my
BPharm (Hons) (UiTM, Malaysia); MSc (Pharmacoepidemiology) (Utrecht University, The Netherlands)
Areas of interest: Pharmacoepidemiology, Methodological research and analytics in epidemiology, Pharmacovigilance, Pharmaceutical health policy
Awards and achievements:
- High Impact Researcher Award, Institute for Clinical Research (2023)
- Excellent Service Award, Ministry of Health Malaysia (2013, 2020)
- Best oral presentation award. Malaysia Stroke Conference (2020, 2023)
- Best poster presentation award. 10th MOH-AMM Scientific Meeting (2013)
- Scholarship award by the Erasmus+ International Credit Mobility Program KA107 – Utrecht University (2022)
- Scholarship award by The ISPE Asian Conference on Pharmacoepidemiology (2020, 2021, 2022)
- Scholarship award by The International Society for Pharmacoepidemiology (ISPE) for the 33rd International Conference on Pharmacoepidemiology, Montreal (2017)
- Scholarship award by Ministry of Health Malaysia (postgraduate study – overseas) (2015)
- Research grant, NMRR-21-822-59745. MOH Malaysia (Sukuk Prihatin), 2021
- Research grant, NMRR-19-3145-51552. MOH-NIH Malaysia, 2019
- Research grant, NMRR-18-379-40587. MOH-NIH Malaysia, 2018
Norazida is a registered pharmacist with the Pharmacy Board Malaysia and a research pharmacist at the Institute for Clinical Research, National Institutes of Health (NIH) Malaysia. She has vast experiences in research and skilled at data analytics, critical appraisal, and writing proposal and manuscript. Her research interests are in drug-related and outcomes research, especially in understanding treatment profiles, effectiveness and safety, and improving health outcomes. She also has an interest in clinical research focusing on medication safety to promote safe prescribing and dispensing in various healthcare settings. She has been actively involved in numerous projects as principal investigator and sub-investigator and has numerous publications in peer-reviewed journals, technical reports, and regularly participate in conferences and scientific meetings that takes place both locally and internationally.
Research Highlights
- SAFECOVAC: a COVID-19 vaccine safety surveillance study in Malaysia that measures the risk of serious adverse events associated with COVID-19 vaccines. Findings from this study is available in peer-reviewed journals and contributes to global safety data on COVID-19 vaccines
- Antibiotic utilisation and prescribing pattern across various healthcare setting and epidemiology of antimicrobial resistance in Malaysia
- Teleconsultation in public primary care clinics in Malaysia: availability of services and acceptance among healthcare workers
- Assessment of treatment profiles of patients with diabetes mellitus in primary care setting
- Provision of stroke thrombolysis services in Malaysia: utilisation rate and identification of challenges in the provision of service
- Comparative effectiveness and safety of antiplatelet therapy for secondary prevention among patients with ischaemic stroke and transient ischaemic attack in Malaysia
Recent Publications
Researcher, Registered Pharmacist
Email: limmf@moh.gov.my
MPharm, MIS, MSc (Epidemiology), PhD
Areas of interest: Cardiovascular epidemiology, Heart failure trials and registries, Natural language processing of clinical trial eligibility criteria and EMR clinical text
Award and Achievements:
- Excellent Service Award, Ministry of Health Malaysia (2012, 2018)
- University Medical Centre Utrecht Global Health Support Program, University Medical Centre Utrecht, Utrecht, the Netherlands (2019)
Yvonne Mei Fong Lim is a researcher trained in clinical epidemiology. Her work uses analytical methods to bring together observational cohorts and clinical trials to estimate generalisability of clinical trials in heart failure and understand the burden and outcomes of patients with heart failure in Malaysia.
She currently leads a cohort study on the effects different low-density lipoprotein cholesterol targets on outcomes in patients with acute myocardial infarction (AMI) (LDL-C TITAN, NMRR ID -22- 02886- BW4 (IIR)). The study involves six hospitals in Malaysia and is expected to provide insight to short- and medium-term management of cardiovascular risks in atherosclerotic cardiovascular disease.
Yvonne’s research focuses on cardiovascular epidemiology in both primary and secondary care settings with a vision to guide and implement interventions which improve access and quality of care. Her other work includes assessing cardiovascular risks in people living with HIV (CardHIV) and validation of AI-based screening tool to detect developmental delay in young children (DADOC-TOY8).
She is also involved research using natural language processing to understand the impact of major inclusion and exclusion criteria in Alzheimer’s disease trials on patient eligibility and diversity with a goal towards more inclusive and generalisable clinical trials.
Research Highlights
Trends for Readmission and Mortality After Heart Failure Hospitalisation in Malaysia, 2007 to 2016 provided national estimates on important HF outcome metrics and contributed epidemiological data to the 2023 clinical practice guidelines for heart failure.
Recent Publications
OurOngoingResearch Projects
Trends and Correlation between Antimicrobial Usage and Resistant Pattern in Malaysia
NMRR ID-23-00234-IBV
This is an observational study aiming to evaluate the trend in antimicrobial utilisation and antimicrobial resistance in Malaysian hospitals setting.
Contact: Audrey Lim
audreylim@moh.gov.my
Impact Evaluation of Policies and Guidelines on Antibiotic Consumption in Primary Care
NMRR ID-21-33-57952
This is a study aiming to evaluate the impact of the various policies and guidelines in place for implementation of prudent and rational antibiotic prescribing in Malaysian public primary care setting.
Contact: Audrey Lim
audreylim@moh.gov.my
Development of Diabetic Retinopathy Risk Score for Primary Care (DR_Score)
NMRR ID-23-00001-9TO
Diabetes retinopathy (DR) has prevalence of 8.5-51.6% in Malaysia. It is important to increase patients' awareness on their DR risk, improve patient empowerment and maximize the resources available in the clinics by risk stratifying the patients for screening. This study aims to derive a DR risk score to be used as a clinical decision support system in Malaysia primary care setting.
Contact: Teh Xin Rou
tehxinrou@crc.moh.gov.my
Impact of COVID-19 on Medicine Utilisation Pattern and Pharmacy Service Utilisation Rates in Malaysia: A Time-series Analysis
NMRR ID-23-00576-L5P
This study aims to measure trends in utilisation patterns of medicine and pharmacy services over time and evaluate the impact of COVID-19 pandemic on these trajectories. Findings from this study will be important to understand the extent and nature of changes in the utilisation pattern. Furthermore, it will serve as a baseline for further evaluation of resource distribution, particularly in terms of service(s) that can efficiently improve health delivery.
Contact: Norazida Ab Rahman
norazida@moh.gov.my
Impact of Low-Density Lipoprotein Cholesterol population Targets In AcuTe myocArdial infarctioN (LDLC-TITAN): Bridging between guidelines and practice
NMRR-ID-22-02886-BW4
LDL-C TITAN is an observational cohort based on the Malaysian NCVD-ACS registry with linkages to the national hospitalisation, TelePrimary health and mortality databases. Its main aim is to determine the differences in cumulative incidence for cardiovascular outcomes between patients who achieve and do not achieve target LDL-C thresholds of <1.8, <1.4 mmol/L, >=50% reduction from baseline levels in patients with acute myocardial infarction.
Contact: Yvonne Lim Mei Fong
limmf@moh.gov.my
Latent Tuberculosis Infection in Malaysia: A Cohort Analysis
NMRR ID-23-03453-QQF
To achieve a TB-free nation by 2035 in alignment with the Sustainable Development Goals (SDGs), addressing both active TB cases and implementing strategies for Latent Tuberculosis Infection (LTBI) is essential. Malaysia has initiated a programmatic strategy focusing on LTBI. This study aims to evaluate the care cascade for LTBI, improving understanding of its management in Malaysia.
Contact: Aslene Yeoh Siu Tjing
aslene@moh.gov.my
The Real-World Evaluation of COVID-19 Vaccines under the Malaysia National COVID-19 Immunisation Program (RECoVaM)
NMRR-21-822-59745
An observational study that leverage on comprehensive surveillance data within a unified framework that describes the COVID-19 pandemic and vaccination rollout in Malaysia. The study aims to evaluate vaccine effectiveness across different sub-populations, vaccination platforms, and variants to facilitate rapid and robust research to guide timely adjustments to national policies related to the COVID-19 vaccination program and epidemic control.
Contact: Masliyana Husin
masliyana.h@moh.gov.my
Case-based Safety Monitoring of Adverse Events Following COVID-19 Vaccination (SAFECOVAC)
NMRR-21-822-59745
SAFECOVAC is an observational study of active safety surveillance for COVID-19 vaccines in Malaysia. The study team evaluates the risk of serious adverse events associated with the administration of COVID-19 vaccines among the vaccinated population. Findings from this study contributes to the local and global safety data of COVID-19 vaccines for recommendation on the COVID-19 immunisation programme.
Contact: Norazida Ab Rahman
norazida@moh.gov.my
Evaluation of the Outpatient Parenteral Antimicrobial Therapy (OPAT) Service in Malaysia
NMRR-24-00941-2C8
This research aims to address these critical questions through a systematic and evidence-based approach. At centers already providing the service, it is imperative to evaluate their performance and understand the underlying factors. The findings and recommendations of this study will help to establish more OPAT centers as well as improve the overall provision of the OPAT service.
Contact: Audrey Lim
audreylim@moh.gov.my
Drug Resistant Tuberculosis in Malaysia: A Retrospective Cohort Study
NMRR ID-24-03029-JGE
This is a retrospective cohort study where registry-based data from the national DR-TB surveillance database will be obtained from TB/Leprosy Sector, Disease Control Division, Ministry of Health Malaysia. The primary aim is to assess the incidence rates and the cascade of care for individuals diagnosed with DR-TB in Malaysia
Contact: Patrick Peng Wee Yao
patrickpeng@moh.gov.my
List of Publications associated with CCORe
1. A comparison between antibiotic utilisation in public and private community healthcare in Malaysia
- Audrey Huili Lim, Norazida Ab Rahman, Siti Nur Su’aidah Nasarudin, Tineshwaran Velvanathan, Mary Chok Chiew Fong, Abdul Haniff Mohamad Yahaya, Sheamini Sivasampu
- Vivek Jason Jayaraj, Masliyana Husin, Jing Lian Suah, Peter Seah Keng Tok, Azahadi Omar, Sanjay Rampal, Sheamini Sivasampu
- Peter Seah Keng Tok, Kong Yeow Kang, Sock Wen Ng, Norazida Ab Rahman, Muhammad Aminul Syahmi, Mohan Dass Pathmanathan, Maheshwara Rao Appannan, Kalaiarasu M Peariasamy, Sheamini Sivasampu
- Wen Yea Hwong, Sock Wen Ng, Seng Fah Tong, Norazida Ab Rahman, Wan Chung Law, Sing Keat Wong, Santhi Datuk Puvanarajah, Aisyah Mohd Norzi, Fiona Suling Lian, Sheamini Sivasampu
- Amanda Wei-Yin Lim, Chin Tho Leong, Mohamad Aziz Salowi, Yvonne Mei Fong Lim, Wen Jun Wong, Wen Yea Hwong
- Kishwen Kanna Yoga Ratnam, Mohd Azmi Bin Suliman, Wan Kim Sui, Peter Seah Keng Tok, Muhammad Fadhli Bin Mohd Yusoff
- Audrey Huili Lim, Norazida Ab Rahman, Su Miin Ong, Siti Raidah Mohamad Azman, Fairus Zana Mohd Rathi, Mastura Ismail, Peter Seah Keng Tok, Bee Kiau Ho, Sheamini Sivasampu
8. Scombroid Poisoning among Prisoners of A Prison in Johor, Malaysia
- Muhamad Farhan Ab Razak, Nor Hana Ahmad Bahuri, Mohamad Nizam Subahir, Farha Ibrahim, Peter Tok Seah Keng, Haidar Rizal Toha, Mohd Rohaizat Hassan, Rozita Hod, Qistina Mohd Ghazali, Mohd ‘Ammar Ihsan Ahmad Zamzuri, Rahmat Dapari, Syed Sharizman Syed Abdul Rahim
- Kuang Hock Lim, Yoon Ling Cheong, Kuang Kuay Lim, Mohd Ruhaizie Riyadzi, Hamizatul Akmal Abd Hamid, Jia Hui Lim, Chee Cheong Kee, Sumarni Mohd Ghazali, Hui Li Lim
- Kuang Hock Lim , Yoon Ling Cheong , Hui Li Lim , Kee Chee Cheong , Mohd Hazilas Mat Hashim , Ali Aman Marine , Yong Kang Cheah , Jia Hui Lim , Sumarni Mohd Ghazali
11. Health-SigQOLM Is a Versatile Scale for Measuring Various Aspects of Health-Related Quality of Life
- Mohamad Adam Bujang, Wei Hong Lai, Selvasingam Ratnasingam, Xun Ting Tiong, Yoon Khee Hon,Eileen Pin Pin Yap, Yvonne Yih Huan Jee, Nurul Fatma Diyana Ahmad, Alex Ren Jye Kim , Masliyana Husin
- Mohamad Adam Bujang, Yoon Khee Hon, Wei Hong Lai, Eileen Pin Pin Yap, Xun Ting Tiong,Selvasingam Ratnasingam, Alex Ren Jye Kim, Masliyana Husin, Yvonne Yih Huan Jee,Nurul Fatma Diyana Ahmad, Cheng Hoon Chew, Clare Hui Hong Tan, Sing Yee Khoo, Fazalena Johari and Alan Yean Yip Fong
13. Concurrent Validity Between EQ-5D and HRQ-6D Measures in Patients with Different Primary Diagnoses
- Mohamad Adam Bujang, Yoon Khee Hon, Wei Hong Lai, Eileen Pin Pin Yap, Xun Ting Tiong,Selvasingam Ratnasingam, Alex Ren Jye Kim, Masliyana Husin, Yvonne Yih Huan Jee,Nurul Fatma Diyana Ahmad, Cheng Hoon Chew, Clare Hui Hong Tan, Sing Yee Khoo, Fazalena Johari and Alan Yean Yip Fong
14. Health-Related Quality of Life with Six Domains (HRQ-6D): Features and Applications
- Mohamad Adam Bujang & Masliyana Husin
- Yvonne Mei Fong Lim, Asselbergs FW, Bagheri A, Denaxas S, Wan Ting Tay, Voors A, Lam CSP, Koudstaal S, Grobbee DE, Vaartjes I
- Norazida Ab Rahman, Ee Vien Low, Audrey Huili Lim, Azzy Iyzati Ahmad Shanizza, See Wan Ho, Mardhiyah Kamal, Abdul Haniff Mohamad Yahaya, Sheamini Sivasampu
- Norazida Ab Rahman, Teck Long King, Kalaiarasu M Peariasamy, Sheamini Sivasampu, SAFECOVAC study group
Centre for Clinical Outcome Research (CCORe)
Institute for Clinical Research (ICR)
National Institutes of Health,
Ministry of Health Malaysia,
Block B4, National Institute of Health (NIH) Complex,
No. 1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam,
40170 Shah Alam, Selangor Darul Ehsan, Malaysia
Main Phone: +603-33628855
Email : ccore.icr@gmail.com
