Clinical Research Centre
Hospital Pulau Pinang
Georgetown, Pulau Pinang
WhoWe Are
Established in 2001 and operational since 2003, Clinical Research Centre Hospital Pulau Pinang (CRC HPP) began in a small office with four staff members at the current CTC clinic, relocated to the 1st floor of the ACC Building in 2009, and expanded to the CRC Complex building in 2019 to enhance support for research activities at Hospital Pulau Pinang. The mission of CRC HPP is to improve patient health outcomes through ethical and high-quality clinical research, while its vision is to synthesize evidence within the Malaysian context to inform and update policies. The objectives of CRC HPP are to conduct and support research by providing essential services and facilities, promote a research culture and enhance research capacity through data resources and training, and produce impactful, evidence-based research to advance the healthcare system.
OurTeam
InvestigatorsHighlight
Head of CRC, Acute Medicine Physician, Hospital Pulau Pinang
Email: dryoonck@moh.gov.my
MBBChBAO (IRE), MRCP (UK), MRCP (IRE), MMed (S’PORE), MBA
Areas of interest: Non-communicable diseases, Maternal health, Diabetes
Awards and achievements:
- Excellent Service Award, Ministry of Health Malaysia (2007, 2012, 2017, 2022)
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Clinical Research Malaysia Award for Top Ministry of Health Study Site - 2022
Dr. Yoon is dedicated to translating the extensive body of research evidence into tangible improvements in community health. His work involves not only applying this knowledge to enhance health outcomes but also shaping the future of clinical practice through the development of guidelines. In addition, Dr. Yoon actively contributes to special interest groups that focus on critical areas such as non-communicable diseases, maternal health, and diabetes. His commitment extends to influencing policy and practice in these fields, aiming to bridge the gap between research and real-world health applications.
Research Highlights
Dr. Yoon has contributed as an author to Clinical Practice Guidelines (CPG) on topics including bronchial asthma in adults, advanced care planning, and urinary tract infections during pregnancy. Additionally, he serves as a reviewer for the Malaysian Clinical Practice Guidelines (CPG) concerning systemic lupus erythematosus, hepatitis B, and rheumatoid arthritis.
Recent Publications
Project Highlights
Incidence and Characteristics of Acute Kidney Injury among Hospitalized Dengue Patients
NMRR ID-23-01702-MJA
Acute kidney injury in dengue has been associated with increased length of hospital stay and mortality in dengue patients. Yet it is one of the least studied complications of dengue. This retrospective observational study aims to determine the incidence of acute kidney injury among all adult dengue patients hospitalized in Hospital Pulau Pinang.
The Malaysian Study on Hemodialysis patients SARS-Cov-2 Vaccination Immune Response: A prospective cohort study
NMRR ID-21-644-59445
This study looks at Covid-19 vaccination in haemodialysis patients, a high-risk group due to their immunocompromised status and comorbidities. It aims to assess immunogenicity in these patients, providing critical data to inform the national vaccination task force's strategy for this vulnerable population.
Epidemiology, incidence, and clinical outcomes of snake bites treated in Hospital Pulau Pinang
NMRR ID-18-2593-43921
Snakebite is an acute medical emergency that necessitates immediate treatment and administration of appropriate antivenoms. This study aims to determine the epidemiology, incidence and clinical outcomes of snake bites treated at Hospital Pulau Pinang over a 10-year period.
Evaluating The Preliminary Outcomes Of Post Thoracic Endovascular Aortic Repair In A Single Center: A Retrospective Descriptive Cross Sectional Study
NMRR ID-24-00148-KX7
Thoracic aortic disease has a complicated and poorly understood pathophysiology. Aneurysms, dissections, traumatic injuries, intramural hematomas, and penetrating herosclerotic ulcers are among these diseases. All patients had TEVAR procedures performed at HPP’s Department of Cardiothoracic Surgery within(2019–2023)receive efficient management of their disease pathology, a retrospective study is being planned.
MyGenom initiative: Establishing a reference genome for precision medicine in Malaysia | |
Ministry of Health (MOH) Biobank, Institute for Medical Research, Ministry of Health | |
NMRR-23-01702-MJA | Incidence and Characteristics of Acute Kidney Injury among Hospitalized Dengue Patients |
NMRR-23-02619-POU | A prospective cohort study on a novel surgical technique Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal diseases in Malaysia. |
NMRR-23-02480-SGV | Prevelance Risk Factor and Etiology of onychomycosis in psoriasis patients |
NMRR-22-02846-I21 | Development and Validation of Usability and Satisfaction of Health Application Questionnaire (USHA) |
NMRR-18-2593-43921 | Epidemiology, incidence, and clinical outcomes of snake bites treated in Hospital Pulau Pinang |
RSCH-23-00281-MGB | Incidence and Characteristics of Acute Kidney Injury among Hospitalized off pump and on pump CABG patients |
NMRR | id - 2024study done in 2024 |
NMRR-20-2951-57003 | A Phase 3, Multicenter, Randomized, Double-Blind Study of MK-7684 with Pembrolizumab as a Coformulation (MK-7684A) Versus Pembrolizumab Monotherapy as First Line Treatment for Participants With PD-L1 Positive Metastatic Non-Small Cell Lung Cancer (TIGIT) |
NMRR-22-02070-23D | A Randomized, Double-blind, Four-Arm Active and Placebo-controlled Dose-Finding Trial to Evaluate the Efficacy, Tolerability, Safety, and Dose Response Of LYT-100 in Patients with Idiopathic Pulmonary Fibrosis (IPF) |
NMRR-23-01871-OBV | A Randomized, Double-Blind, Parallel Group, Multicenter 12 Week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants with Inadequately Controlled Asthmas (LITHOS) |
NMRR-23-00606-M4P | MASTER PROTOCOL: A Phase 2, Open-label, Multi-arm Study of Tislelizumab in Combination With Investigational Agents With or Without Chemotherapy in Patients With Previously Untreated, Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer |
NMRR-24-00102-YRK | A Randomised, Placebo-Controlled, Double-Blind, Multi-Centre, 4-week, 3-way Crossover Pharmacodynamic Study to Assess the Equivalence of Budesonide, Glycopyrronium, and Formoterol Fumarate (BGF) Delivered by MDI HFO Compared with BGF Delivered by MDI HFA in Participants with Chronic Obstructive Pulmonary Disease |
NMRR-24-01815-KDL | Studies of Heart & Kidney Protection with BI 690517 in combination with empagliflozin: A multicenter, international, randomized, double-blind, placebo-controlled clinical trial of the aldosterone synthase inhibitor BI 690517 in combination with empagliflozin in patients with chronic kidney disease |
NMRR-23-01854-V44 | A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed Treatment With Osimertinib (SAFFRON) |
List of Publications associated with CRC HPP
- Assessment of the nlmixr R package for population pharmacokinetic modeling: A metformin case study
- Wen Yao Mak, Qing Xi Ooi, Cintia Valeria Cruz, Irene Looi, Kah Hay Yuen, Joseph F Standing
- Baclofen prescribing practice and its appropriateness in an outpatient setting of a tertiary hospital
- Ch’ng CC, Ng RS, Wee HC, T’ng SLC, Ong LM
- Early outcomes of short-course low intensity shockwave therapy (LiSWT) for erectile dysfunction: A prospective, randomized, double blinded, sham-controlled study in Malaysia
- Ong WLK, Lechmiannandan S, Lim YL, et al.
- Changes in blood pressure after Messenger RNA COVID-19 vaccination
- Ch’ng CC, Ong LM, KM Wong
- Simple and high sample throughput LC/ESI-MS/MS method for bioequivalence study of prazosin, a drug with risk of orthostatic hypotension
- Loh, G. O. K., Wong, E. Y. L., Tan, Y. T. F., Wee, H. C., Ng, R. S., Syed, H. K., & Peh, K. K.
- Comparing the efficacy of tocilizumab with corticosteroid therapy in treating COVID-19 patients: a systematic review and meta-analysis
- Lim PC, Wong KL, Retha R, Chong MF, Chow TS, Sivasangari S, Lee CY
- Lim PC, Wong KL, Retha R, Chong MF, Chow TS, Sivasangari S, Lee CY
Services at CRC Hospital Pulau Pinang
CRC HPP provides training through workshops and consultations:
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Statistical consultation
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Protocol development
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Research design
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Project management
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Randomization
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Sample size calculation
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NMRR registration
Meet Our Collaborators
Upcoming Activities
Highlighted Activities
Good Clinical Practice
24th April – 26th April 2024
Enrichment & engagement Visit to CTU Hosp Ampang
10th May 2023
Northern Research Camp
- 12th June -14th June 2024
BIOBANK training
- 24th July 2023
Liason Officer Training Workshop
- 12th July 2024
Enrichment & engagement visit to CRC HUS
- 19th Sept 2023
ICR & DR Aaron Neal (NIH, USA) visit to CRC HPP
- 8th Sept 2022
NPRA audit
- 25th Sept -27th Sept 2023
CRC Hospital Pulau Pinang
Main Phone: +604-2225580/5578